Owner Vertex Pharmaceuticals Incorporated

Inventors Aronov, Alex; Come, Jon H.; Davies, Robert J.; Pierce, Albert C.; Wang, Jian; Nanthakumar, Suganthini; Cao, Jingrong; Bandarage, Upul K.; Krueger, Elaine; Tiran, Amaud Le; Liao, Yusheng; Messersmith, David; Collier, Philip N.; Grey, Ronald; O'Dowd, Hardwin; Henderson, James A.; Grillot, Anne-Laure

Agent Baldwins

Pub. Number AU-A-2010341573

PCT Pub. Number WO2011/087776

Priority 61/369,201 30.07.10 US; 61/387,582 29.09.10 US; 61/289,003 22.12.09 US; 61/350,631 02.06.10 US

Filing date 21 December 2010

Wipo publication date 21 July 2011

C07D 401/04 Heterocyclic compounds containing two or more hetero rings

A61K 31/352 - condensed with carbocyclic rings, e.g. cannabinols, methantheline

A61K 31/424 - condensed with heterocyclic ring systems, e.g. clavulanic acid

A61K 31/429 - condensed with heterocyclic ring systems

C07D 401/14 Heterocyclic compounds containing two or more hetero rings

C07D 405/14 Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D 417/14 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 471/04 Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 471/20 Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 491/20 Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or

A61P 9/00 Drugs for disorders of the cardiovascular system

A61P 29/00 Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 37/00 Drugs for immunological or allergic disorders