Owner LIGAND PHARMACEUTICALS INC.

Inventors Zhi, Lin; Hudson, Andrew R.; Van Oeveren, Cornelis A.; Roach, Steven L.; Pedram, Bijan; Shen, Yixing; Valdez, Lino J.; Basinger, Jillian; Grant, Virginia Heather Sharron; Pickens, Jason C.

Agent Griffith Hack

Pub. Number AU-A-2010307006

PCT Pub. Number WO2011/046954

Priority 61/251,259 13.10.09 US

Filing date 12 October 2010

Wipo publication date 21 April 2011

C07C 251/86 (2006.01) Compounds containing nitrogen atoms doubly- bound to a carbon skeleton

A61K 31/15 (2006.01) - Oximes (CNO)

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/18 (2006.01) - Sulfonamides

A61K 31/245 (2006.01)

A61K 31/343 (2006.01) - condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone

A61K 31/36 (2006.01)

A61K 31/381 (2006.01) - having five-membered rings

A61K 31/4015 (2006.01) - having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide

A61K 31/402 (2006.01) - 1-aryl-substituted, e.g. piretanide

A61K 31/4025 (2006.01) - not condensed and containing further heterocyclic rings, e.g. cromakalim

A61K 31/404 (2006.01)

A61K 31/4045 (2006.01)

A61K 31/405 (2006.01)

A61K 31/41 (2006.01) - having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole

A61K 31/415 (2006.01) - 1,2-Diazoles

A61K 31/4155 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/416 (2006.01) - condensed with carbocyclic ring systems, e.g. indazole

A61K 31/4164 (2006.01) - 1,3-Diazoles

A61K 31/4184 (2006.01)

A61K 31/4192 (2006.01) - 1,2,3-Triazoles

A61K 31/421 (2006.01) - 1,3-Oxazoles, e.g. pemoline, trimethadione

A61K 31/423 - condensed with carbocyclic rings