Owner Astellas Pharma Inc.

Inventors Yoshihara, Kousei; Suzuki, Daisuke; Yamaki, Susumu; Koga, Yuji; Seki, Norio; Fujiyasu, Jiro; Neya, Masahiro

Agent Davies Collison Cave

Pub. Number AU-A-2010296420

PCT Pub. Number WO2011/034078

Priority 2009-214991 16.09.09 JP

Filing date 15 September 2010

Wipo publication date 24 March 2011

C07C 237/04 (2006.01) Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

A61K 31/165 (2006.01) - having aromatic rings, e.g. colchicine, atenolol, progabide

A61K 31/166 (2006.01) - having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/17 (2006.01) - having the group NC(O)N or NC(S)N, e.g. urea, thiourea, carmustine

A61K 31/18 (2006.01) - Sulfonamides

A61K 31/216 (2006.01)

A61K 31/27 (2006.01)

A61K 31/277 (2006.01)

A61K 31/351 (2006.01) - not condensed with another ring

A61K 31/357 (2006.01) - having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K 31/4035 (2006.01)

A61K 31/4402 (2006.01) - only substituted in position 2, e.g. pheniramine, bisacodyl

A61K 31/4406 (2006.01) - only substituted in position 3, e.g. zimeldine

A61K 31/4418 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine

A61K 31/4439 (2006.01)

A61K 31/451 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine

A61K 31/454 (2006.01)

A61K 31/4545 (2006.01)

A61K 31/472 (2006.01) - Non-condensed isoquinolines, e.g. papaverine

A61K 31/495 (2006.01) - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

A61K 31/496 - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene