Owner Shire LLC

Inventors Franklin, Richard; Golding, Bernard T.; Tyson, Robert G.

Agent Baldwins

Pub. Number AU-A-2010264703

PCT Pub. Number WO2010/149760

Priority 61/269,458 24.06.09 US

Filing date 24 June 2010

Wipo publication date 29 December 2010

C07C 233/64 (2006.01) Carboxylic acid amides

A61K 31/155 (2006.01) - Amidines (), e.g. guanidine (HNC(NH)NH), isourea (HNC(OH)NH), isothiourea (HNC(SH)NH)

A61K 31/165 (2006.01) - having aromatic rings, e.g. colchicine, atenolol, progabide

A61K 31/17 (2006.01) - having the group NC(O)N or NC(S)N, e.g. urea, thiourea, carmustine

A61P 9/06 (2006.01) Drugs for disorders of the cardiovascular system

C07C 237/08 (2006.01) Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

C07C 275/16 (2006.01) Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups

C07C 279/14 (2006.01) Derivatives of guanidine, i.e. compounds containing the group the singly-bound nitrogen atoms not being part of nitro or nitroso groups

C07C 323/60 (2006.01) Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

C07D 213/81 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 213/82 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members