Owner Genentech, Inc. F. Hoffmann-La Roche AG

Inventors Castanedo, Georgette; Chan, Bryan; Goldstein, David Michael; Kondru, Rama K.; Lucas, Matthew C.; Palmer, Wylie Solang; Price, Stephen; Safina, Brian; Savy, Pascal Pierre Alexandre; Seward, Eileen Mary; Sutherlin, Daniel P.; Sweeney, Zachary Kevin

Agent Griffith Hack

Pub. Number AU-A-2010254161

PCT Pub. Number WO2010/138589

Priority 61/181,452 27.05.09 US; 61/287,607 17.12.09 US

Filing date 26 May 2010

Wipo publication date 2 December 2010

C07D 487/04 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups

A61K 31/519 (2006.01) - ortho- or peri-condensed with heterocyclic rings

A61P 9/00 (2006.01) Drugs for disorders of the cardiovascular system

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 35/00 (2006.01) Antineoplastic agents

C07D 491/04 (2006.01) Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or

C07D 513/04 (2006.01) Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups , or