Compounds and methods for inhibiting NHE-mediated antiport in the treatment of disorders associated with fluid reten- tion or salt overload and gastrointestinal tract disorders

Details for Australian Patent Application No. 2009334511 (hide)

Owner Ardelyx, Inc.

Inventors Charmot, Dominique; Jacobs, Jeffrey W.; Leadbetter, Michael Robert; Navre, Marc; Carreras, Chris; Bell, Noah

Agent Davies Collison Cave

Pub. Number AU-A-2009334511

PCT Pub. Number WO2010/078449

Priority 61/141,853 31.12.08 US; 61/169,509 15.04.09 US; 61/237,842 28.08.09 US

Filing date 30 December 2009

Wipo publication date 8 July 2010

International Classifications

C07C 311/29 (2006.01) Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups

A61K 31/18 (2006.01) - Sulfonamides

A61K 31/472 (2006.01) - Non-condensed isoquinolines, e.g. papaverine

A61K 31/4725 (2006.01)

A61K 31/517 (2006.01) - ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine

A61K 31/662 (2006.01) - Phosphorus acids or esters thereof having PC bonds, e.g. foscarnet, trichlorfon

A61K 31/675 (2006.01) - having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate

A61K 45/06 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

C07D 217/04 (2006.01) Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems

C07D 401/12 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07F 9/38 (2006.01) Compounds containing elements of the 5th Group of the Periodic System

C07F 9/40 (2006.01) Compounds containing elements of the 5th Group of the Periodic System

C07F 9/572 (2006.01) Compounds containing elements of the 5th Group of the Periodic System

C07F 9/62 (2006.01) Compounds containing elements of the 5th Group of the Periodic System

Event Publications

21 July 2011 PCT application entered the National Phase

  PCT publication WO2010/078449 Priority application(s): WO2010/078449

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