Owner Vertex Pharmaceuticals Incorporated

Inventors Charrier, Jean-Damien; Durrant, Steven; Kay, David; Knegtel, Ronald; Maccormick, Somhairle; Mortimore, Michael; O'Donnell, Michael; Pinder, Joanne; Rutherford, Alistair; Virani, Anisa Nizarali; Young, Stephen; Reaper, Philip Michael

Agent Baldwins

Pub. Number AU-A-2009327357

PCT Pub. Number WO2010/071837

Priority 61/181,794 28.05.09 US; 61/219,100 22.06.09 US; 61/139,429 19.12.08 US; 61/139,424 19.12.08 US; 61/139,426 19.12.08 US; 61/139,420 19.12.08 US

Filing date 18 December 2009

Wipo publication date 24 June 2010

C07D 413/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

A61K 31/497 (2006.01)

A61P 35/00 (2006.01) Antineoplastic agents

C07D 401/14 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 403/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 409/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D 413/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 417/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 417/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 471/04 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups