Compositions and methods for inhibiting expression of transthyretin

Details for Australian Patent Application No. 2009307677 (hide)

Owner Alnylam Pharmaceuticals, Inc.

Inventors Sah, Dinah Wen-Yee; Hinkle, Gregory; Alvarez, Rene; Milstein, Stuart; Chen, Qingmin

Agent Griffith Hack

Pub. Number AU-A-2009307677

PCT Pub. Number WO2010/048228

Priority 61/115,738 18.11.08 US; 61/156,670 02.03.09 US; 61/242,783 15.09.09 US; 61/185,545 09.06.09 US; 61/244,794 22.09.09 US; 61/106,956 20.10.08 US

Filing date 20 October 2009

Wipo publication date 29 April 2010

International Classifications

A61K 31/13 (2006.01) - Amines, e.g. amantadine

A61K 31/713 (2006.01) - Double-stranded nucleic acids or oligonucleotides

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

C12N 15/113 (2010.01) Mutation or genetic engineering - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

C07H 21/02 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Event Publications

19 May 2011 PCT application entered the National Phase

  PCT publication WO2010/048228 Priority application(s): WO2010/048228

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