Owner Amgen Inc.

Inventors Medina, Julio C.; Jiao, Xian Yun; Kim, Yong-Jae; Kohn, Todd J.; Vimolratana, Marc; Pattaropong, Vatee; Luo, Jian; Li, An-Rong; Xiong, Yumei; Cao, Qiong; Zhang, Jie; Brown, Sean P.; Swaminath, Gayathri; Yang, Li; Yu, Ming; Lin, Daniel; Su, Yongli; Lai, Sujen; Wang, Xiang; Du, Xiaohui; Schwarz, Margrit; Houze, Jonathan; Reagan, Jeffrey D.; Zhu, Liusheng; Shen, Wang; Dransfield, Paul J.; Fu, Zice; Liu, Jiwen; Wang, Yingcai

Agent Shelston IP

Pub. Number AU-B-2008311355

PCT Pub. Number WO2009/048527

Priority 60/998,786 10.10.07 US; 61/068,724 06.03.08 US

Filing date 3 October 2008

Wipo publication date 16 April 2009

Acceptance publication date 19 January 2012

C07C 59/68 (2006.01) Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, CHO, keto, ether, groups, groups, or groups

A61K 31/192 (2006.01)

A61K 31/4415 (2006.01) - Pyridoxine, i.e.vitamin B

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

C07C 217/54 (2006.01) Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton

C07C 323/19 (2006.01) Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups

C07D 213/64 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members