Owner Allergan, Inc.

Inventors Ngo, Vinh X.; Old, David W.

Agent Davies Collison Cave

Pub. Number AU-B-2007272730

PCT Pub. Number WO2008/008660

Priority 60/806,972 11.07.06 US; 60/806,946 11.07.06 US

Filing date 2 July 2007

Wipo publication date 17 January 2008

Acceptance publication date 1 November 2012

C07C 59/72 Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, CHO, keto, ether, groups, groups, or groups

A61K 31/192

A61K 31/275 - Nitriles

A61K 31/34 - having five-membered rings with one oxygen as the only ring hetero atom, e.g. isosorbide

A61K 31/381 - having five-membered rings

A61K 31/395 - having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins

A61K 31/426 - 1,3-Thiazoles

A61P 27/06 Drugs for disorders of the senses

C07C 255/57 Carboxylic acid nitriles

C07D 213/61 Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 277/56 Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings

C07D 307/80 Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D 333/36 Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D 409/12 Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07F 9/38 Compounds containing elements of the 5th Group of the Periodic System