Owner Vertex Pharmaceuticals Incorporated

Inventors Chen, Minzhang; Perni, Robert B.; Zlokarnik, Gregor; Tanoury, Gerald J.; Jung, Young Chun; Forslund, Raymond E.; Bennani, Youssef; Maltais, Francois

Agent Spruson & Ferguson

Pub. Number AU-B-2007227544

PCT Pub. Number WO2007/109080

Priority 60/782,976 16.03.06 US; 60/782,788 16.03.06 US; 60/844,771 15.09.06 US

Filing date 14 March 2007

Wipo publication date 27 September 2007

Acceptance publication date 1 November 2012

C07C 231/20 Preparation of carboxylic acid amides

A61K 31/403 - condensed with carbocyclic rings, e.g. carbazole

A61K 31/422 - not condensed and containing further heterocyclic rings

A61K 31/498 - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine

A61P 31/12 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

C07C 237/04 Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

C07D 209/52 Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D 403/12 Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 403/14 Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 498/10 Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms