Cyclohexyl sulphones as gammasecretase inhibitors

Details for Australian Patent Application No. 2003269211 (hide)

Owner Merck Sharp & Dohme Limited

Inventors Thomson, Joanne; Harrison, Timothy; Nadin, Alan John; Shaw, Duncan Edward; Churcher, Ian; Williams, Susannah; Owens, Andrew Pate; Kerrad, Sonia

Agent Spruson & Ferguson

Pub. Number AU-B-2003269211

PCT Number PCT/GB03/04196

PCT Pub. Number WO2004/031139

Priority 0223038.1 04.10.02 GB

Filing date 25 September 2003

Wipo publication date 23 April 2004

Acceptance publication date 28 May 2009

International Classifications

C07C 317/30 (2006.01) Sulfones

A61K 31/10 (2006.01)

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

C07D 213/70 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 213/74 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 231/18 (2006.01) Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings

C07D 233/42 (2006.01) Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings

C07D 249/12 (2006.01) Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms

C07D 257/04 (2006.01) Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms

C07D 261/10 (2006.01) Heterocyclic compounds having nitrogen and oxygen as the only ring hetero atoms

C07D 275/03 (2006.01) Heterocyclic compounds having nitrogen and sulfur as the only ring hetero atoms

C07D 277/36 (2006.01) Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings

C07D 295/088 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D 307/64 (2006.01) Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D 333/34 (2006.01) Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D 275/02 (2006.01) Heterocyclic compounds having nitrogen and sulfur as the only ring hetero atoms

Event Publications

15 January 2004 Complete Application Filed

  Priority application(s): 0223038.1 04.10.02 GB

27 May 2004 Application Open to Public Inspection

  Published as AU-B-2003269211

28 May 2009 Application Accepted

  Published as AU-B-2003269211

18 June 2009 Application for Amendment

  The nature of the amendment is as shown in the statement(s) filed 25 May 2009. Address for service in Australia - Spruson & Ferguson Level 35 St Martins Tower 31 Market Street Sydney NSW 2000

15 October 2009 Amendment Made

  The nature of the amendment is as shown in the statement(s) filed 25 May 2009

22 October 2009 Standard Patent Sealed

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