Owner Janssen Pharmaceutica N.V.

Inventors Van Brandt, Sven Franciscus Anna; Van Emelen, Kristof; Backx, Leo Jacobus Jozef; Verdonck, Marc Gustaaf Celine

Agent Shelston IP

Pub. Number AU-B-2003212336

PCT Number PCT/EP03/02512

PCT Pub. Number WO2003/076395

Priority PCT/EP02/14074 10.12.02 EP; 60/363,799 13.03.02 US

Filing date 11 March 2003

Wipo publication date 22 September 2003

Acceptance publication date 18 December 2008

C07D 295/14 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/4439 (2006.01)

A61K 31/444 (2006.01)

A61K 31/4468 (2006.01) - having a nitrogen atom directly attached in position 4, e.g. clebopride, fentanyl

A61K 31/451 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. glutethimide, meperidine, loperamide, phencyclidine, piminodine

A61K 31/4545 (2006.01)

A61K 31/4709 (2006.01) - Non-condensed quinolines containing further heterocyclic rings

A61K 31/4725 (2006.01)

A61K 31/506 (2006.01) - not condensed and containing further heterocyclic rings

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 35/00 (2006.01) Antineoplastic agents

C07C 259/10 (2006.01) Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups

C07D 207/09 (2006.01) Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D 207/14 (2006.01) Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D 211/58 (2006.01) Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D 213/78 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 217/02 (2006.01) Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems

C07D 239/42 (2006.01) Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D 295/155 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D 295/26 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

C07D 307/68 (2006.01) Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D 401/04 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 401/12 Heterocyclic compounds containing two or more hetero rings